St Mary Cathedral

St Mary Cathedral A Roman Catholic Church built in 1868. Weekend Masses: Saturday :4:30, Sunday 7, 8:30, 10:30 AM
Confession on Sat.: 3:15-4:15 PM

Join us.
06/19/2026

Join us.

This page provides guidance on how to participate in the Rosary Billion Prayer Offering for World Youth Day Seoul 2027.

06/14/2026

Mass at Saint Mary of the Annunciation Cathedral in Cape Girardeau, Missouri

All Content and Music are used under permission obtained via Onelicense -722382

It’s never too late to sign up.
05/31/2026

It’s never too late to sign up.

Reminder: Vacation Bible School starts next week—June 1-June 5 (9:00AM-12:00PM)! 🇻🇦Prekindergarten through fifth grade are invited to climb aboard the Vatican Express bus 🚌 and tour the Vatican treasures.🇻🇦
The cost is $15 per child which includes a digital download of music 🎶 and snacks.

05/30/2026

Are you planning on inviting a family member, friend, or neighbor to Mass this weekend?

05/29/2026

If you or someone you know is thinking about becoming Catholic or simply wants to know more about the Catholic faith, email OCIA at [email protected]

05/29/2026

Continue to invite your family members who have fallen away from the church to a meaningful and intentional relationship with Jesus; may you be an excellent witness to the faith.

Pope Leo XIV is inviting Catholics around the world to join him in praying the Rosary for peace on May 30.
05/28/2026

Pope Leo XIV is inviting Catholics around the world to join him in praying the Rosary for peace on May 30.

Address

615 William Street
Cape Girardeau, MO
63703

Opening Hours

Monday 9am - 5pm
Tuesday 9am - 5pm
Wednesday 9am - 5pm
Thursday 9am - 5pm
Friday 9am - 5pm

Telephone

+15733359347

Website

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