02/19/2026
As our climate continues to change - sometimes for the better, but often times dramatically and for the worse - please keep the following in mind for those of you living with Sickle Cell Anemia:
Sickle cell anemia (SCA), also known as sickle cell disease, is a hereditary condition that alters the shape and function of red blood cells.[1–3] While the disease is primarily caused by a mutation in the HBB gene, environmental factors, including temperature, humidity, and air quality, can exacerbate its effects.[4] With global climatic changes ongoing, the implications for individuals with SCA are increasingly significant.[5] The frequency and intensity of heatwaves are increasing worldwide due to climate change. Elevated temperatures can trigger vaso-occlusive crises, a hallmark of SCA, causing severe pain and organ damage in affected individuals. Additionally, extreme cold weather can lead to vasoconstriction, potentially increasing the risk of sickle cell crisis and tissue damage.[6–8] Climate change can influence regional patterns of precipitation and humidity, affecting the risk of dehydration for individuals with SCA. Dehydration can trigger sickling of red blood cells and lead to painful crises. Changes in water availability may also affect the ability of SCA patients to maintain adequate hydration, potentially influencing their health outcomes.[9–11]
SOURCE:
Sickle cell anemia (SCA) is a hereditary blood disorder characterized by abnormal hemoglobin, causing red blood cells to assume a sickle shape, leading to various complications. Climate change has emerged as a significant global challenge, ...